cardiomyopathy Archives - USF Health News https://hscweb3.hsc.usf.edu/blog/tag/cardiomyopathy/ USF Health News Thu, 21 Nov 2019 19:57:12 +0000 en-US hourly 1 https://wordpress.org/?v=6.5.3 Clinic integrates care and genetic research for patients with neuromuscular disorders https://hscweb3.hsc.usf.edu/blog/2019/11/15/clinic-integrates-care-and-genetic-research-for-patients-with-neuromuscular-disorders/ Fri, 15 Nov 2019 21:54:58 +0000 https://hscweb3.hsc.usf.edu/?p=29817 //www.youtube.com/watch?v=xAWQcqqrnIs USF Health has established a Neurocardiogenetics Clinic focused on improving the quality of life for patients with hereditary neuromuscular disorders who are at risk for or already […]

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USF Health has established a Neurocardiogenetics Clinic focused on improving the quality of life for patients with hereditary neuromuscular disorders who are at risk for or already experiencing cardiac complications. Innovative genetic research is a central component of the new clinic.

The multidisciplinary clinic teams faculty and staff with clinical expertise in cardiology, genetics and neurology. The clinic is directed by Aarti Patel, MD, assistant professor of cardiology and director of the Cardiac Imaging Fellowship Program at USF Health in collaboration with Thomas McDonald, MD, professor of cardiology and molecular pharmacology and physiology, and a member of the USF Health Heart Institute, and Theresa Zesiewicz, MD, professor of neurology and director of the USF Health Ataxia Research Center. Patients receive a complete cardiac examination and testing along with a comprehensive family genetic evaluation from providers familiar with their neurological history.

“Combining all that information, we are able to come up with a personalized treatment plan,” Dr. Patel said.

Many patients initially seen at the Neurocardiogenetics Clinic have been diagnosed with Friedreich’s ataxia (FA), a rare, debilitating and life-shortening neuromuscular disorder that usually strikes in childhood. At some point in their lives 55 to 60-percent of FA patients develop some form of cardiac disease. The most devastating of these is cardiomyopathy, a heart muscle disease that limits blood pumped to the rest of the body and increases risk for heart failure and abnormal heart rhythms.

“FA is a multisystem disease that affects many different parts of the body, including the heart,” Dr. Zesiewicz said. “And one of its most sinister complications is cardiomyopathy, an enlarged heart.”

The Neurocardiogenetic clinic offers patients and their families the opportunity to participate in ongoing genetic studies exploring potential links between heart disease and neuromuscular diseases like FA and certain types of other ataxias and muscular dystrophies.

Dr. Aarti Patel (left), assistant professor of cardiology, collaborates with Dr. Thomas McDonald, professor of molecular pharmacology and physiology, at the new USF Health Neurocardiogenetics Clinic. Dr. Theresa Zesiewicz. professor of neurology (not pictured), is another collaborator.

While a deficiency in the frataxin protein can lead to fibrosis and scarring of heart muscle tissue in FA, competing theories exist about how a genetic mutation may actually result in heart problems in this particular ataxia and other neuromuscular disorders.

Dr. McDonald’s research team is searching for answers to many questions, including how different genetic variations may lead to cardiac abnormalities and affect the severity of heart disease.

Small blood samples are collected from patient volunteers with different inherited neuromuscular and/or cardiac disorders, as well as family members who are unaffected genetic carriers of neuromuscular diseases. In laboratory cell culture dishes, USF Health researchers genetically reprogram the blood cells into pluripotent stem cells that can grow into any cell type. Then they induce these stem cells — containing the same genetic make-up as the patient who provided blood — to become nerve cells and heart muscle cells.

The goal is to work out at a molecular level how FA or other inherited neuromuscular diseases damage the heart muscle. Once that is achieved, Dr. McDonald said, the “disease in a dish” can be used to identify potential drug targets and test treatment options on the patient’s own cells.

“With stem cell technology and disease-in-a-dish modeling, we’re looking for the earliest changes in either a heart or a nerve cell (that lead to disease),” he said. “A big unanswered question is whether the molecular or cellular process happening in the nerve is the same as that damaging the heart muscle. By using stem cell-based research we hope to be able to determine if there is a connection between the nerve and the heart – or whether it’s a separate, independent process but based upon the same genetic defect.”

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The collaborative research builds upon robust data collected by doctors in the clinic, including the wide range of symptoms seen in patients with hereditary neurological disorders involving cardiac complications.

Ultimately, that can help improve understanding of why genetic variations in certain neuromuscular diseases cause cardiac complications, Dr. McDonald said. “Having a clear clinical picture of each research participant will help us correlate the genetics and function of cells we see in the laboratory with how that translates to disease progression in the individual.”

“With careful clinical surveillance and novel biomarkers, our hope is that we will be able to predict which patients and their family members are at highest risk for cardiovascular disease so we can intervene early with effective treatment,” Dr. Patel said. “We’re hoping to identify patients even before they develop cardiac symptoms, so we can prevent heart disease.”

-Video and photos by Allison Long, USF Health Communications and Marketing



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Heart Institute hosts first research symposium https://hscweb3.hsc.usf.edu/blog/2018/09/25/heart-institute-hosts-first-research-symposium/ Tue, 25 Sep 2018 19:14:31 +0000 https://hscweb3.hsc.usf.edu/?p=26262 The USF Health Heart Institute recently hosted its inaugural scientific conference, marking another milestone in the young Institute’s short history and setting a standard for future collaborative work […]

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The USF Health Heart Institute recently hosted its inaugural scientific conference, marking another milestone in the young Institute’s short history and setting a standard for future collaborative work that seeks to halt cardiovascular disease.

The 1st Annual Scientific Colloquium was held Sept. 24 on the USF campus and welcomed several dozen faculty researchers from throughout the USF research community.

A photo showing at the inaugural Heart Institute Scientific Colloquium are, from left, Sam Wickline, Lee Sweeney, Sami Noujaim and Charles Lockwood.

At the inaugural Heart Institute Scientific Colloquium are, from left, Sam Wickline, Lee Sweeney, Sami Noujaim and Charles Lockwood.

“This is a key moment for the USF Health Heart Institute and we are proud to launch an event that showcases impactful cardiovascular research,” said Samuel Wickline, MD, professor and the Tampa General Hospital Endowed Chair for Cardiovascular Research, interim chair of the USF Health Department of Cardiovascular Sciences, and director of the USF Health Heart Institute.

“This inaugural Heart Institute Scientific Colloquium welcomed scientists from across our field to hear about new approaches to heart research. We also know this event is a great example of our collaborative, multidisciplinary approach to scientific discovery. Real progress in cardiovascular research happens when the scientific community works together.”

The Heart Institute in the USF Health Morsani College of Medicine (MCOM) conducts several collaborative projects with researchers from Duke, Stanford, Albert Einstein College of Medicine (NY), University of Michigan, Washington University in St. Louis, MO, and others, he said.

“This Colloquium offers a glimpse of that, showing how our Heart Institute researchers are working with experts from other institutions.”

The keynote speaker for the Colloquium was Lee Sweeney, PhD, professor of pharmacology and therapeutics and director of the Myology Institute at the University of Florida. His talk, titled “The Dilated Cardiomyopathy Associated with Duchenne Muscular Dystrophy,” addressed ways to improve heart failure in children with Duchenne muscular dystrophy (DMD), the most common fatal genetic condition in children. DMD affects mostly boys and is caused by a genetic mutation that prevents the body from producing dystrophin, a protein essential for strong muscle fibers, including those by the heart.

A photo with Dr. Lee Sweeney at podium presenting his work.

Dr. Lee Sweeney presents his work on cardiomyopathy associated with Duchenne muscular dystrophy.

“Dr. Sweeney’s work dovetails beautifully with efforts taking place in the Heart Institute,” Dr. Wickline said.

In addition to Dr. Sweeney, two current Heart Institute research scientists offered overviews of their current research: Jerome Breslin, PhD, and Sami Noujaim, PhD.

Dr. Breslin, professor of molecular pharmacology and physiology at MCOM, presented “Targeting S1P Receptors to Reduce Inflammation and Microvascular Permeability.”

“Our work focuses on finding new ways to reduce the negative impact of inflammation after injury or during disease,” Dr. Breslin said. “Specifically, we are identifying the molecular signaling pathways that initiate, sustain, and resolve leakage of plasma proteins from the blood into the surrounding tissues, which is what causes swelling. To date our work suggests a key role for a compound known as sphingosine-1-phosphate, which is normally released by circulating blood cells, as a key contributor to maintain the walls of blood vessels and reduce plasma protein leakage.”

And Dr. Noujaim, associate professor of molecular pharmacology and physiology at MCOM, presented “Antiarrhythmic Block of Potassium Inward Rectifiers in Atrial Fibrillation.”

“Atrial fibrillation (AF) is the most common arrhythmia seen in the clinic and is increasingly recognized as a disease of aging, and as a significant cause of morbidity and mortality,” Dr. Noujaim said. “For instance, it has been found that AF independently increases mortality and that it is associated with dementia, and is a major risk factor for stroke. AF is very challenging to treat with currently used antiarrhythmic drugs. It has been found that the aberrant working of a class of proteins called cardiac potassium channels perpetuates AF. My lecture showed how we used a widely prescribed antimalarial drug to correct the function of these potassium channels, and consequently stop AF. Our studies used mathematical modeling, and sophisticated experiments, from the level of the single molecule, all the way to the patient’s heart to understand how this antimalarial drug could stop AF and restore the heart’s normal rhythm. We hope that such studies will help us to find a novel class of therapies that can potentially be effective in treating AF.”

A photo of audience looking at presentation slide.

Dr. Lee Sweeney’s work focuses on cardiomyopathy associated with Duchenne muscular dystrophy.

The Colloquium was also a celebration of what’s to come, Dr. Wickline said.

“We’ve had a busy year so far with progress on our building in downtown Tampa, great success in recruiting more prominent scientists to our Heart Institute roster, and increases in research funding,” Dr. Wickline said. “This momentum, and these close collaborations, indicate that people are perking up their ears about USF Health, the Heart Institute and all of our developments here.

“But we aren’t stopping here,” he added. “This is an exciting time for cardiovascular disease research and, over the next year, we will see more research emphasis on regenerative medicine, heart failure, bioinformatics, and molecular and functional imaging. As our Heart Institute continues to outfit our building and our team, we continually seek foundational research and philanthropic funding and collaborative opportunities.

“All of this will help us attract the best and the brightest and truly impact cardiovascular disease.”

Photos by Torie Doll, USF Health Communications

 



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USF Health cardiologist studies genetic predisposition to sudden cardiac death https://hscweb3.hsc.usf.edu/blog/2018/07/29/usf-health-cardiologist-studies-genetic-predispostion-to-sudden-cardiac-death/ Sun, 29 Jul 2018 05:36:40 +0000 https://hscweb3.hsc.usf.edu/?p=25706 In the laboratory and the clinic, Dr. Thomas McDonald focuses on inherited heart diseases that can lead to potentially deadly heart rhythm disturbances //www.youtube.com/watch?v=0mdWzfFOqHY Sudden cardiac death most […]

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In the laboratory and the clinic, Dr. Thomas McDonald focuses on inherited heart diseases that can lead to potentially deadly heart rhythm disturbances

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Sudden cardiac death most often makes the news when athletes in peak physical condition collapse and die while exercising or competing.  This spring, Zeke Upshaw, 26, a basketball player for the Grand Rapids Drive, a G-league affiliate of the Detroit Pistons, collapsed face-down on home court during the final minute of a game and later died at the hospital. A medical examiner ruled that he had suffered sudden cardiac death.

“Sudden cardiac death is when someone, usually otherwise healthy and often young, tragically drops dead – without any warning,” said Thomas V. McDonald, MD, a professor in the USF Health Department of Cardiovascular Sciences.

Most of the 200,000 to 450,000 sudden cardiac deaths each year in United States are caused by heart rhythm disturbances  provoked by certain strenuous activities, prescription medications, recreational drugs, or other triggers. “Sometimes it just happens in your sleep.  The most severe and earliest form would be sudden infant death, or SIDS,” Dr. McDonald said.

Physician-scientist Thomas McDonald, MD, a professor in the USF Health Department of Cardiovascular Sciences and member of the USF Health Heart Institute, with his laboratory team.

Dr. McDonald was recruited to the USF Health Heart Institute in October 2017 from Albert Einstein College of Medicine in New York City, where he was a professor of both cardiology and molecular pharmacology. He also co-directed the thriving Montefiore-Einstein Clinic for CardioGenetics, the first such interdisciplinary clinic in metropolitan New York for families at risk of sudden cardiac death from arrhythmias.

At USF Health his laboratory continues to focus on the fundamental causes of heart conditions passed from one generation to the next — and what can be done to help prevent disease and its consequences.  The hereditary conditions he studies include those affecting the heart’s electrical system to cause arrhythmias, like long QT syndrome and Brugada syndrome, and those affecting heart muscle, such as hypertrophic cardiomyopathy and dilated cardiomyopathy.  While rare, these conditions can substantially increase an individual’s risk for sudden cardiac death and devastate families.

In long QT syndrome, the heart takes longer than normal to recharge between beats. This electrical disturbance, called a prolonged QT interval, can often be seen on an electrocardiogram (ECG) like the one pictured here.

Dr. McDonald has also started a USF Health Cardiogenetics Clinic, modeled after the Montefiore-Einstein center he co-founded, to evaluate and treat families in which members succumb to unexplained sudden cardiac death or SIDS, or where suspicion of an underlying, hereditary heart rhythm disturbance exists.

His work bridging the laboratory and clinic has implications for a much larger population than people with relatively rare inherited cardiac disorders.  Dr. McDonald points to growing evidence of the interplay between genetics and environmental factors like diet, exercise and stress.

“By studying these rare or uncommon cardiac diseases,” he said, “we may uncover more generalizable biochemical pathways that could be influenced to harm the heart given the wrong environment — even in genetically unaffected families.”

COPH sound-icon-png Studying uncommon (inherited) heart diseases to gain better insight into more common ones.

 

Dr. McDonald lifts a container including pluripotent stem cells from storage in liquid oxygen. Alexander Bertalovitz, PhD, (right) an assistant professor of cardiovascular sciences who helps manage the cardiogenetics laboratory, followed Dr. McDonald to USF Health from Albert Einstein College of Medicine in New York City.

Pinpointing the meaning of genetic variants of “unknown significance”

Dr. McDonald analyzes genetic changes, or mutations, which may lead to malfunctioning of ion channels that create electrical signals in the heart.

His team has spent the last few years characterizing the function of 1,000 different mutations found in cardiac ion channel genes associated with hereditary rhythm conditions such as long QT syndrome and Brugada syndrome. The researchers recreate the genetic variations in a cellular model and use automated electrophysiology techniques to analyze how the mutations affect the ion channel’s ability to correctly generate each heartbeat. All these variations have been cited in published scientific literature; however, it is still largely unclear which ones truly increase the risk of abnormal rhythms leading to palpitations, seizures, fainting or sudden death – and which are benign.

The research project is supported by a five-year, $1.7 million R01 grant from the NIH’s National Health, Lung and Blood Institute.

“Our ultimate goal is to work with other investigators to create a NIH-curated public database that physicians and genetic counselors could access to find out whether a genetic variant is likely, or unlikely, to cause a potentially life-threatening heart rhythm disturbance in a patient or their family members,” Dr. McDonald said.

As genetic testing is becomes more common, a growing challenge is that lab reports of people referred for DNA sequence testing often come back listing many “variants of unknown significance,” Dr. McDonald said. “That drives physicians and patients crazy because they don’t know what that means… what do they do with that information?”

Dr. McDonald with Jiajia Yang, a PhD student in the Department of Molecular Pharmacology and Physiology.

An important step toward improving the guidance that doctors offer individuals with inherited heart disorders would be the ability to more precisely distinguish between disease-causing mutations and mutations with little or no harmful physiological effects through a resource like a scientifically validated database, he added.

Recommended treatment options for long QT are life-long and vary, including regular cardiac monitoring, taking medication such as beta blockers, restricting strenuous sports activities, or sometimes implanting pacemakers or defibrillators to help control abnormal heartbeats.  So, for example, if DNA testing of a child or young adult revealed a long QT genetic variation characterized as having little risk of leading to sudden cardiac death, prescribing beta blockers and routine cardiac monitoring might be the best preventive therapy – avoiding the long-term management and small, but real, lifetime risk of complications from an implantable device.

COPH sound-icon-png Dr. McDonald comments on the focus of his laboratory’s research on genetic variations.

Opening Tampa Bay region’s first CardioGenetics Clinic

The twice-monthly Cardiogenetics Clinic, which opened in March, is held at USF Health Cardiology’s Armenia Avenue location. The new clinic is staffed by a team with the expertise to address the diverse medical, psychological, social and ethical issues arising when evaluating genetic heart conditions that predispose patients to sudden cardiac death.

Dr. McDonald — with certified genetic counselor Melissa Racobaldo (far left) and clinical geneticist Christopher Griffith, MD — leads a comprehensive discussion of family medical history with a patient and his mother referred to the USF Health Cardiogenetics Clinic.

“When I arrived there was no formal cardiogenetics program in the greater metropolitan area of Tampa Bay where 4 million people live — so the prospect of building one from scratch was very attractive,” said Dr. McDonald, who specializes in adult cardiology. He leads the clinic working with USF Health faculty members Christopher Griffith, MD, assistant professor of pediatrics and a clinical geneticist; and Melissa Racobaldo, a genetic counselor; as well as Gary Stapleton, MD, a pediatric interventional cardiologist from Johns Hopkins All Children’s Hospital. USF College of Public Health students specializing in genetic counseling are expected to join the clinic in coming months.

Many with congenital cardiac conditions have no signs or symptoms. Patients and their families referred to the clinic typically have experienced a history of arrhythmias or other cardiac events, or suffered the unexpected death of a loved one.

During the initial visit, families meet with team members for a cardiac history and examination, review of medical records and/or autopsy reports, and baseline tests that include an electrocardiogram and echocardiogram.  Based on the family’s medical history, a tree-like chart known as the DNA pedigree is created to identify familial genetic patterns and sudden unexpected deaths linked to cardiac disorders.  “The most important genetic test is still a complete family history,” Dr. McDonald said.

Certified genetic counselor Melissa Racobaldo consults with Dr. McDonald about a patient.

DNA testing is usually only recommended when the team discerns that the pattern of cardiac-related events is highly likely to be genetic rather than environmental.  For instance, a family history indicating that a few relatives died from heart disease in their 80s might be considered environmental.

If a mutation is found in one of the genes known to be associated with a dangerous cardiac arrhythmia, then the first (affected) patient who got tested receives immediate counseling by a cardiologist, and genetic testing and counseling will be offered to all at-risk relatives. Different heart rhythm genetic mutations have different effects on ion channels, so individualized remedies are required.

“Genetics is still quite complex to most people, so we try to make our explanations understandable and not so scary,” said Dr. McDonald, who has co-authored several articles on how patients are affected by cardiogenetic testing, including in the journals Qualitative Health Research and Personalized Medicine.

“Our dominant message is ‘we’re here to provide information, which gives you knowledge, and knowledge gives you power to manage your life and to help the next generation.”

A pedigree, which depicts the relationship between individuals and relevant facts about their medical histories, can be used to help understand the transmission of genes within the family. Dr. McDonald points to a square indicating the presence of a particular genetic trait in a male.

The Cardiogenetics Clinic will offer patients access to the latest clinical trials for new drugs or devices. Dr. McDonald was recently named USF site lead investigator for a world-wide Phase 3 study testing the effect on walking endurance of an investigational medication for patients with dilated cardiomyopathy caused by a rare genetic mutation. This form of heart disease, in which inadequate pumping of blood causes the heart to become weaker, can lead to heart failure.

“Heart in a dish” as a drug screening tool

Interested in drug discovery for inherited heart diseases lacking effective medications, Dr. McDonald’s lab has begun collecting blood cells from USF Health cardiomyopathy patients who provide informed consent.

The adult blood cells can be genetically reprogrammed into induced pluripotent stem cells (iPSCs) with the potential to develop into any cell type in the body, including heart cells.  The goal is to model the early stages of inherited heart disease with patient-specific cells grown in a petri dish, working out at a molecular level how the disease does its damage to heart muscle.

COPH sound-icon-png On the horizon: Modeling inherited heart diseases using pluripotent stem cells

 

Dr. McDonald and Maliheh Najari Beidokhti, PhD, a postdoctoral associate in the Department of Cardiovascular Sciences.

“Once you do that,” Dr. McDonald said, “you can use the ‘heart disease in a cell culture dish’ to screen any number of drugs or chemical compounds for their potential therapeutic benefit.”

Dr. McDonald is also collaborating with colleagues in the USF Health Department of Neurology to look at rare genetic mutations for nervous system diseases, such as certain types of muscular dystrophy and ataxias, which can lead to severe heart damage,

Dr. McDonald received his bachelor’s degree in zoology from USF in 1977 and MD degree from the University of Florida.  He completed a residency in medicine and research fellowship in cardiology at Columbia-Presbyterian Medical Center in New York City. At Stanford University School of Medicine, he conducted fellowships in clinical cardiology and interventional cardiology, as well as a postdoctoral research fellowship. He spent 22 years as a faculty member at Albert Einstein College of Medicine before joining the USF Health Morsani College of Medicine last fall.

Continuously funded throughout his career by the NIH or the American Heart Association (AHA), Dr. McDonald has authored more than 70 peer-reviewed publications.   Among his many high-impact papers was a 2013 article published in FASEB.  The NIH-supported study was among the first to report that synonymous (silent) changes in DNA traditionally considered neutral may adversely affect the processing speed and efficiency of ion channels associated with the heart arrhythmia syndrome Long QT and alter disease severity.

Dr. McDonald has served on multiple study sections of the NIH and AHA. He was elected in 2011 as an AHA Fellow-Basic Cardiovascular Sciences Council.

Dr. McDonald says his clinical practice helps inform and complement the translational science he conducts in the laboratory.

Some things you may not know about Dr. McDonald

  • During high school, he worked one year as a head cook for a restaurant in Winter Park, Fla., before entering college. “It made me realize that hard work is important, but also motivated me to study so I could make a living by using my head more than my hands.”
  • Wife Kami Kim, MD, also a USF Health physician-scientist, is a professor with joint appointments in the Department of Internal Medicine and in the Department of Global Health. They met in the cardiac intensive care unit at Columbia Presbyterian Medical Center when Dr. McDonald was a resident and Dr. Kim was rounding as a medical student.  Their two sons, both studying theoretical math, are Clayton, 24, a PhD student at Boston College, and Vaughan, 20, starting his junior year at Harvard University.
  • McDonald enjoys bicycling, Japanese cooking, and nearly exclusively reads fiction – “it’s another window on the human condition.” His two favorite books are One Hundred Years of Solitude, an acclaimed novel by Nobel Prize-winning Latin-American author Gabriel García Márquez, and Infinite Jest, a literary bestseller and unconventional comedy by David Foster Wallace.

-Video and photos by Torie M. Doll, USF Health Communications and Marketing



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