Archive forJuly, 2008

USF College of Nursing gets $3.5M to establish VA Nursing Academy

July 31, 2008 -- The University of South Florida College of Nursing is partnering with James A. Haley Veterans Hospital to expand education for nursing students and health care for veterans.

USF was competitively selected as one of seven nursing schools across the nation this year to join the VA Nursing Academy. The nursing school was awarded a $3.5 million grant from the VA for the partnership. The Academy is a virtual organization that boosts learning opportunities for nursing students at VA facilities, funds additional faculty positions to increase baccalaureate student enrollment, and increases recruitment and retention of nurses.

Read more...
- Department of Veterans Affairs news release

- St. Petersburg Times article

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USF receives new multimillion dollar award to assess juvenile diabetes treatments

The latest major NIH contract to USF’s Jeffrey Krischer and his team - $128 million - will coordinate worldwide studies looking for ways to prevent and treat childhood diabetes

Virtually every major center conducting type 1 diabetes research is now linked to the USF Pediatric Epidemiology Center led by Jeffrey Krischer, PhD

Tampa, FL (July 31, 2008) -- The National Institutes of Health has awarded $127.7 million to the University of South Florida research team led by Jeffrey Krischer, PhD, to coordinate worldwide studies on the prevention and treatment of juvenile diabetes. This latest funding, a seven-year award, supports Dr. Krischer’s coordination of the NIH network of clinical research centers known as TrialNet.

The award adds to the $169 million received last year by Dr. Krischer, a professor of pediatrics, to coordinate studies examining the causes of juvenile diabetes. That previously funded 10-year NIH study, known as TEDDY (The Environmental Determinants of Diabetes in the Young), is seeking to explain why the incidence of diabetes in the very young has doubled since the 1980s. The $169-million contract was the largest in USF’s history.

“Dr. Krischer’s new TrialNet award will catapult USF to the top 50 for NIH funding to medical schools,” said Stephen Klasko, MD, MBA, senior vice president for USF Health and dean of the College of Medicine. “Almost every major effort worldwide to eliminate type 1 diabetes for the next generation comes through here.”

"Jeff sees connections other people don't see. He uses tools in new ways to solve very complex problems," said Karen Holbrook, PhD, Vice President for Research at USF. "It's an extraordinary program that is doing as much as any program today for people around the globe. It is innovative, and it is important."

“Jeff’s efforts continue to enhance our excellence in research in the area of diabetes and related diseases”, said Abdul S. Rao, MD. MA. DPhil, Senior Associate Vice President, USF Health. “This current grant goes a long way in establishing USF’s dominance in this field and the recognition by the NIH of the extraordinary scientific strides that have been made by Jeff and his colleagues”.

Type 1 diabetes, also known as juvenile diabetes, is one of the most common and serious long-term diseases in children and adolescents. It is a disease in which the body’s immune system attacks the cells that make insulin – a hormone that keeps blood sugar levels stable. Its treatment requires a life-long commitment to daily insulin injections and significant lifestyle changes.

TrialNet will screen more than 150,000 children and adults, identifying those with early signs of diabetes to investigate new therapies that may arrest disease progression. Other studies include treatments of newly diagnosed patients to prevent continued loss of insulin production capability. These treatments, if proven successful, may be tested to determine if they can yield new prevention strategies. In addition to heading the data coordinating and technology center for TrialNet, Dr. Krischer chairs one of the major prevention studies within the consortium – a clinical trial investigating whether oral insulin can prevent or delay diabetes in a specific group of people at risk for type 1 diabetes.

TEDDY is screening more than 300,000 newborns and following 8,000 for up to 15 years to investigate the role that diet, infections, and other environmental factors may play in the disease process. Dr. Krischer chairs the study itself as well as directing TEDDY’s data coordinating center.

Both TrialNet and TEDDY are being carried out on an international stage through clinical sites in the United States, Canada, Europe, Australia and New Zealand

The two projects complement each other, with virtually every major university and medical center conducting type 1 diabetes research now linked to Dr. Krischer’s Pediatric Epidemiology Center at USF. The center is pooling the clinical consortiums’ efforts to understand the triggers of diabetes and to develop strategies to prevent or improve treatment. Data describing the everyday lives of study participants, results from research laboratories across the globe, and the clinical course of the disease in affected individuals flow into USF on a continual basis.

All that data is analyzed at USF and shared with scientists, clinicians and investigators worldwide with the goal of putting an end to type 1 diabetes, Dr. Krischer said. “This team effort would not be possible without the outstanding group of 50-plus researchers at USF working on these studies. They are recognized world experts in developing new technologies and informatics applied to medicine,” he said. “The research in diabetes complements our other projects in rare diseases, many of which are also autoimmune diseases and share a common etiological pathway. The hope is that our efforts can lead to improvements for all those affected.”

Dr. Krischer, an epidemiologist, has attracted more than $389 million in research funding to USF.

- USF Health -

USF Health is dedicated to creating a model of health care based on understanding the full spectrum of health. It includes the University of South Florida’s colleges of medicine, nursing, and public health; the schools of biomedical sciences as well as physical therapy & rehabilitation sciences; and the USF Physicians Group. With $308 million in research funding last year, USF is one of the nation’s top 63 public research universities and one of Florida’s top three research universities.

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Global Health Infectious Disease Research Open House

Dennis Kyle, PhD, professor of global health, looks through a portal door of the new insectary, which will soon house malaria-carrying mosquitoes.

Most days you can't just walk into the laboratories where members of the College of Public Health's Global Health Infectious Disease Research (GHIDR) team do their work, seeking to unravel the secrets of viral and parasitic infectious diseases transmitted by insects. But, July 28, GHIDR welcomed visitors for tours of the team's offices and state-of-the-art laboratories, covering nearly 15,000 square feet of space in the Interdisciplinary Research Building at USF's Research Park.

The team's faculty core is comprised of five scientists who together have accumulated more than 120 years of expertise in global infectious diseases research -- John Adams, PhD; Dennis Kyle, PhD; Wil Milhous, PhD; Thomas Unnasch, PhD; and Alberto van Olphen, PhD, DVM. They collaborate with the neighboring USF Center for Biological Defense and the Florida Department of Bureau of Laboratories, among others.

The tour stopped outside the newly commissioned, top-security BSL-3 Lab, for a brief glimpse in the window. But, visitors did get to go inside the recently completed Vector-Borne Pathogen Laboratory, or insectary, where the hot, humid air will soon welcome swarms of carefully contained, blood-sucking mosquitoes that transmit the malaria parasite.

Read more about the GHIDR Team...

Photo Gallery

- Newsbrief by Anne DeLotto Baier/USF Health Communications
- Photos by Eric Younghans/USF Health Media Center

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Crist announces Draper deal, including R&D center at USF

TAMPA, Fla. (July 28, 2008) – Governor Charlie Crist and Draper Laboratory's CEO Jim Shields today announced Cambridge, Mass.-based Charles Stark Draper Laboratory, Inc., one of the world's leading independent research and development laboratories engaged in applied research, engineering and development, will be establishing a BioMEMS R&D Center at the University of South Florida in Tampa and a Multi Chip Module (MCM) Center in St. Petersburg.

Read full news release...

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USF Health Checkup with Dr. Klasko

Dear Colleagues,

In the last week alone, USF Health opened the Morsani Center, a research team received a new $128 million grant to end juvenile diabetes, and USF recruited MIT's spin-off Draper Laboratories. These news events, for me, mean the next few years are a "tipping point" for the future of USF Health. In fact, it's a tipping point for how we organize health and health care for our entire region.

On Sunday, an editorial in The Tampa Tribune said the same thing. The editorial advocated that it is time for Tampa to move to the next level in health care.

The key, the Tribune argued, is USF Health:

“To enhance the stature of our region, Tampa Bay's health care leaders should maximize our assets, forego silos and find more places to develop and co-brand programs with USF Health.

“It's time to decide. Does this region want some of the nation's best hospitals, or do we want to continue sending patients elsewhere?”

Click here to read Tribune's full editorial...

This is no small challenge. Let’s take a gut check heading into academic year 08/09. There’s nothing easy about our economic climate. There’s nothing easy about the challenges USF faces along with our region. But there’s also evidence that your creativity is yielding results.

Challenge: To build and retain our core strength, our faculty members.

Results: We’ve developed academic investment systems to help faculty advance, while recruiting amazing new faculty members … Alicia Monroe, Tom Unnasch, Tanya Murphy, Cliff Gooch, Nick Hall, Todd Hazelton, Lew Rubin, Kevin Kip – just to name a few. Like them, each of you have made USF the right place to build your future.


Challenge:
To forego silos that prevented our success in studies of aging and the brain.

Results: We’re now seeing the future of neurosciences at USF as a model of “sky is the limit” thinking with a revitalized neurology department, a world class center for neuro-immunology in nursing, a powerful neurosurgery department, a psychiatry department opening new fields of treatment, and the new merger between USF and the Byrd Alzheimer’s Institute.

Challenge: To create dramatic change in education to build the health care future.

Results: Check out the success of our students in nursing, the successful accreditation visit in medicine despite rapid change in our medical education, a sterling site visit for physical therapy. How about our upcoming College of pharmacy as the completion of the most innovative, integrated health science experiment in the country.

Challenge: To join our community partners in elevating health care.

Results: Start first with the deep outreach public health has achieved, including substantial transformation in East Tampa. Check our progress toward rational and stronger partnerships with Moffitt, Tampa General and All Children’s, based on USF’s role as a leader in developing world class programs along with its partners.

Challenge: To use research to teach and model transformational discovery.

Results: Take a look at the diversification of our research portfolio across USF Health, with important new worldwide centers in nursing and public health. I’m delighted to acknowledge the new $128 million grant to help end juvenile diabetes, awarded by the NIH to Jeff Krischer to add to his prior $169 million grant.

As we complete our checkup, we need to recognize that the landscape of USF Health has changed – from the incredible infectious disease team in new laboratories in public health, to the new building for nursing, and now this last week we saw our first patients in the Morsani Center for Advanced Health Care.

These buildings model our response to the challenge of the future of health care. We believe our colleges can transform how we understand the full spectrum of health. We believe our education will transform how our students change the world. And we believe that transformational research will drive how we do everything.

I am committed to making the next few years the “tipping point” years for USF Health’s success despite the external challenges. I’ve been personally flattered to be approached for other leadership positions, because those recruitments prove that the work you’ve done has been recognized. But I’m staying here. There is no place that has the potential and excitement of a transformed health system that USF Health is leading.

To all of our students, faculty and staff, thank you for everything you do every day to meet the challenge.

Steve

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First, Do No Harm

A new multicollege course for graduates students, the first of its kind at USF, taps into a team approach for improving patient safety

University of South Florida senior medical student Lonna Gordon knows a thing or two about medical mistakes. Gordon worked as a retail pharmacist before entering medical school.

“So many times I received prescriptions to fill and the amount was dead wrong – the dosage was actually toxic,” said Gordon.

She recalls one time she had to be very persistent about calling and talking her way through several emergency room staffers before she was finally able to speak to the physician who had written a prescription for 0.5 mg of Clonidine three times a day – an exceedingly high dosage for that blood pressure medication. Noticing that the patient waiting in the pharmacy for her to fill the prescription appeared agitated, Gordon questioned whether the ER doctor meant to write the script for Klonopin, a medication used to treat anxiety. He had.

Gordon was one of the first students to sign up for USF’s new interdisciplinary course Human Error and Patient Safety, which will bring together graduate students from the Colleges of Medicine, Nursing, Public Health, Engineering (industrial engineering), and Arts and Sciences (aging studies, anthropology, communication, psychology, social work). The three-month course, starting Aug. 27, will be the first of its kind at USF, and possibly the country, said Peter Fabri, MD, PhD, associate dean for graduate medical education at USF.

Part of the “Year of Patient Safety” initiative at USF, the course is intended to be one important step in laying the educational foundation needed to promote a culture of patient safety.

“I’m really excited about this course,” said Dr. Fabri, a surgeon who holds a doctorate in industrial engineering with an emphasis on patient safety. “We have a unique ability to make a real difference.”

A leading cause of death and injury

The 1999 Institute of Medicine report To Err is Human estimated that avoidable errors in U.S. hospitals were killing 44,000 to 98,000 Americans a year and injuring thousands more. These “adverse events” include everything from wrong-site surgery, anesthesia-related mistakes and treatment delays to medication errors, patient falls and deaths related to patient transfers.

“If you accept the data in the IOM report, that would be the equivalent of one jumbo jet filled with passengers crashing every day for a year.” Dr. Fabri said. “And that doesn’t count hundreds, if not thousands of near misses that occur in our hospitals every day.”

Dr. Fabri will co-direct the course with Jay Wolfson, JD, PhD, a distinguished service professor of public health and medicine director of the Suncoast Center for Patient Safety at USF. They are assisted by a steering committee of multi-college faculty instructors comprised of Karen Liller, PhD, associate dean of public health; Mary Webb, PhD, associate dean of nursing; Eric Eisenberg, PhD, interim dean of arts and sciences; and Jose Zayas-Castro, PhD, professor and chair of industrial and management systems engineering.

Combining lectures, case study discussions and renowned visiting experts in patient safety (see link to experts at end of story), the course is designed to promote teamwork by putting students in interdisciplinary groups to work on patient safety projects. In fact, the first class will be launched with a session and practical exercises, led by Michael Brannick, PhD, of USF Industrial/Organizational Psychology, on how to function effectively as a team member. Over the semester each team will develop a recommendation to resolve a real patient safety problem identified by Tampa General Hospital.

Typically, medicine has viewed all errors as failings – expecting clinicians to be fault-free and blaming and shaming individuals when a mistake occurs.

Some have argued this punitive approach provides an incentive for health care professionals not to report their mistakes or those of colleagues. In addition, the “captain of the ship” culture in which physicians are trained and practice may inhibit other health care workers from speaking out when they notice an error is about to occur.

Improving patient safety a team effort

The IOM report prompted legislative and regulatory initiatives designed to analyze, report and monitor medical errors and search for solutions. But the educational aspect needed to create a cultural shift toward patient safety has lagged, said Dr. Fabri.

“In spite of all the rhetoric about teamwork, our country’s medical students are still trained to be autonomous, not team players. So we’re preparing highly competitive individuals, when what we need are professionals who can work together for a common good -- the best outcome for the patient,” he said. “The only way you can change culture is to bring people with different skill sets together so they can begin talking about patient safety problems and thinking outside the box of their traditional disciplines.”

Medical student Gordon is looking forward to learning other students’ perspectives about ways to improve patient safety. “Physicians don’t have enough time or all the expertise to do everything their patients need. In order to effectively and safely deliver care you have to collaborate with others, and most of us have not been trained how to do that…. It’s important for health professionals not to antagonize each other, but to help strengthen and act as checks and balances for one another.”

Students from each discipline will bring something of value to the table when it comes to strategies for reducing health-related errors, say faculty involved in the new course.

USF surgical residents at Moffitt Cancer Center use a whiteboard to list specifics such as site of impending surgery, any medications that could affect the operation's safety, medical risk factors and names of all the staff working the OR case.

While physicians and, to some extent nurses, are primarily focused on the health and well being of individual patients, public health professionals take a broader, population approach and emphasize prevention, said the College of Public Health’s Dr. Liller. “How could this one improvement impact the safety of the patient population? What might we do in the first place that could prevent that error from ever happening again?”

Industrial engineers are trained to figure out how to do things better. They consider aspects of human behavior when engineering systems to improve quality and productivity in working environments, said the College of Engineering’s Dr. Zayas-Castro. When it comes to designing patient safety solutions, getting to know the challenges, constraints, concerns and viewpoints of health care professionals who work on the frontlines of patient care is as valuable as being able to quantify processes and measure data, he added. “The level of complexity in any clinical organization or healthcare facility today makes it extremely difficult to derive the best solution with just one viewpoint or discipline.”

Confronting the inevitability of error

Dr. Wolfson goes so far as to say the course might actually help protect future physicians from malpractice suits -- maybe even save their licenses. “Doctors talk to people all day long, but they don’t communicate very well,” he said. “The single most significant variable associated with adverse events and the bringing of successful malpractice cases to court has been poor communication.


“Our goal is to help students understand that patient safety is an interdisciplinary issue requiring them to think critically before they act, communicate with lots of people, and take nothing for granted," Dr. Wolfson said.

While there is no entirely risk-free environment, Dr. Wolfson said, much can be done to mitigate error through such measures as changing medication shapes or colors to help prevent mixups and confusion about dosages and developing standardized checklists for surgery. “Health professionals can’t prevent all errors, but we can certainly identify where and when most errors occur and build in better systems to reduce their likelihood,” he said. “And, equally important, we have an obligation to fix something as soon as we realize it’s wrong. By exercising that obligation we’ll help create more trust in the health care system.”


The slogan for the USF Year of Patient Safety initiative is “Measure Twice, Cut Once.” The proverb originated with carpenters as a reminder that if you cut wood improperly the piece is ruined. In other words, it’s faster and better to double-check than make a mistake.

Dr. Fabri says that finding ways to make impending errors transparent may be the most effective way to prevent more errors from happening. Before they can do that, physicians, nurses and other health professionals need to accept the idea that error is an inevitable part of the human condition, even among highly trained, conscientious individuals. “Overconfidence in the system can be disastrous,” he said. “Human beings, by their very nature, will always make mistakes. So, we need to train our students to recheck what they do and recheck what their colleagues do, to speak up if they have doubts, and to be constantly vigilant.”

- Story by Anne DeLotto Baier/USF Health Communications

Related links:

- Course features leading experts in patient safety

- Applying airline safety standards to the OR

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Dr. Cuevas appointed to Heart Association Affiliate Research Committee

Javier Cuevas, PhD, associate professor of Molecular Pharmacology and Physiology, has been appointed to a four-year term on the Affiliate Research Committee of the American Heart Association for the Southeast region of the United States.

Among the charge of committee members is helping select research programs funded by the Affiliate; resolving ethical and policy concerns; establishing funding recommendations; advising the AHA Research Committee as requested; and supporting the Affiliate's promotion of research awareness, including public education, marketing and advocacy issues.

Newsbrief by Anne DeLotto Baier/USF Health Communications

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USF neuroscientist's research selected as Scientific Highlight of the Year

Angelman syndrome research by USF Health neuroscientist Edwin Weeber, PhD, and collaborators, published last year in Nature Neuroscience, was chosen as the Scientific Highlight of the Year by the Federation of European Neuroscience Societies (FENS).


In a study detailed in the March 2007 issue of Nature Neuroscience, Weeber and colleagues essentially cured mice with the mutation that causes Angelman syndrome, a rare genetic disorder characterized by mental retardation, movement and balance problems, and seizures. They reversed all the animals’ neurological deficits by preventing the inhibition of CaMKII, an enzyme critically involved in learning and memory functions at synapses. Their findings may point to new therapeutic targets for the debilitating disorder, which affects approximately one in 15,000 children.

Weeber joined USF as an associate professor of Molecular Pharmacology and Physiology last summer. The research was published by Nature Neuroscience while he was a faculty member at Vanderbilt University Medical Center in Nashville, TN.

Founded in 1998, FENS represents a large number of national European neuroscience societies and several monodisciplinary societies. It is the successor organization of the European Neuroscience Association and the European partner of the American Society for Neuroscience. FENS was founded to advance research and education in neuroscience and to represent neuroscience research in the European Commission, IBRO, and other granting bodies.

Dr. Weeber’s work focuses on how neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s disease, schizophrenia and bipolar disorder, affect human cognitive ability. He has received several national awards, including the National Alliance for Research on Schizophrenia and Depression Young Scientist Award and the American Federation for Aging Research Award.

- Anne DeLotto Baier/USF Health Communications

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Editorial: Leverage USF Health Assets

An editorial appearing in the July 27, 2008 issue of The Tampa Tribune points out that nearly all the Florida hospitals on U.S. News & World Reports' recently released Best Hospitals in America list are affiliated with medical schools. This includes the only two making the nation's best list in the Tampa Bay area -- Tampa General Hospital and Moffitt Cancer Center. The commentary advocates what Dr. Stephen Klasko, dean of the USF College of Medicine and senior vice president for USF Health, has been emphasizing all along: To build the region's stature, the area's health care leaders need to find ways to develop and co-brand programs with USF Health.

Read Tampa Tribune editorial...

Related Link:
USF Health physicians help hospital partners climb in national rankings

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