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Jennie White presents a new method for deriving thresholds of toxicological concern

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On April 30, Jennie White successfully defended her dissertation proposal “Development of a Novel Method for Deriving Thresholds of Toxicological Concern (TTCs) for Vaccine Constituents” to her committee and members of the toxicology program.  Ms. White conducted her research at the Division for Vaccines and Related Products Applications (DVRPA) within the U.S. Food and Drug Administration.

For more than 20 years, the Center for Food Safety and Nutrition (CFSAN) used TTCs as regulatory limits for food contact materials. Numerous European regulatory agencies have adopted them as well.

Ms. White’s project involved the use of an algorithm that divides the reference set of chemicals into classes of presumed high or low toxicity. This is based on the presence or absence of functional groups that are associated with toxic effects on living systems. If this method is validated, it may provide a useful screening aid for new vaccine compounds of unknown toxicity.

Ms. Jennie White is a doctoral candidate the USF College of Public Health, Department of Environmental and Occupational Health. The department offers concentrations in toxicology and risk assessment that lead to MPH, MSPH, and PhD degrees. Most recently, the college launched an online graduate certificate in toxicology.

 

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