University of South Florida

Patents

All entries for U.S. patents issued to Morsani College of Medicine faculty members were provided by the USF Technology Transfer Office:

Title: Microfluidic-coupled in vitro model of the blood-brain barrier
Patent number: 11,198,842
Date issued: 12/14/2021
Inventor(s): Mohapatra; Subhra, Mohapatra; Shyam S., Wang; Tao and Martinez; Taylor

Title: Prevention of preterm birth (PTB) by inhibition of FKBP51
Patent number: 11,197,868
Date issued: 12/14/2021
Inventor(s): Lockwood; Charles, Guzeloglu-Kayisli; Ozlem, Kayisli; Umit and Schatz; Frederick

Title: ALDA-1 treatment and prevention of pulmonary disease
Patent number: 11,185,528
Date issued: 11/30/2021
Inventor(s): Kolliputi; Narasaiah, Lockey; Richard F. and Galam; Lakshmi

Title: Immunogenic proteins against Clostridium difficile
Patent number: 11,173,198
Date issued: 11/16/2021
Inventor(s): Sun; Xingmin

Title: Detection of cancer by elevated levels of bcl-2
Patent number: 11,156,613
Date issued: 10/26/2021
Inventor(s): Kruk; Patricia A.

Title: Methods of measuring C19MC miRNA in a post-natal tissue and uses thereof
Patent number: 11,155,880
Date issued: 10/26/2021
Inventor(s): Totary-Jain; Hana and Mong; Ezinne Francess

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Title: Bone Fusion System
Patent number: 11,134,997
Date issued: 10/05/2021
Inventor(s): Vrionis; Frank D., Aghayev; Kamran,, Gonzalez Blohm; Sabrina A., and Doulgeris; James J.

Title: PKC-delta-I inhibitor formulations and uses thereof
Patent number:  11,129,808
Date issued: 9/28/2021
Inventor(s): Patel; Niketa A., Patel; Rekha S., Sparks; Robert Pleasants, and Guida; Wayne Charles

Title: Targeted delivery of molecules using impedance-based monitoring at elevated temperatures
Patent number: 11,123,554
Date issued: 9/21/2021
Inventor(s): Heller; Richard, Heller; Loree C., and Jaroszeski; Mark Jeffery

Title: Method of delivering genes and drugs to a posterior segment of an eye
Patent number: 11,110,183
Date issued: 9/07/2021
Inventor(s): Mohapatra; Shyam S., Mohapatra; Subhra and Markousta; Eleni

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Title: PTEN binding compounds, formulations, and uses thereof
Patent number: 11,078,164
Date issued: 08/03/21
Inventor(s): Dave; Vrushank G. And Cai; Jianfeng

Title: System and method of measuring cell viability and growth
Patent number: 11,016,062
Date issued: 05/25/21
Inventor(s): Mohapatra; Shyam S., Mohapatra; Subhra, Guldiken; Rasim Oytun, Nair; Rajesh R. and Wang; Tao

Title: Peptibodies, compositions thereof, and methods of treating atrial fibrillation
Patent number: 11,014,971
Date issued: 05/25/21
Inventor(s): Noujaim; Sami Fouad and Teng; Michael

Title: Plasma derived from human umbilical cord blood for the treatment of neurodegenerative disorders
Patent number: 11,007,230
Date issued: 05/18/21
Inventor(s): Garbuzova-Davis; Svitlana, Ehrhart; Jared Carl and Sanberg; Paul R.

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Title: Osteoconductive and osteoinductive implant for augmentation, stabilization, or defect reconstruction
Patent number:  10,987,448
Date issued: 4/27/2021
Inventor(s): Ching; Jessica A., Ford; Jonathan Michael and Decker; Summer Joy

Title: Antithrombotic nanoparticles and methods for treating necrotizing enterocolitis
Patent number:  10,987,315
Date issued: 4/27/2021
Inventor(s): Maheshwari; Akhil, Wickline; Samuel, Namachivayam; Kopperuncholan and, Pan; Hua

Title: Exogenous ketone supplements for reducing anxiety-related behavior
Patent number:  10,980,764
Date issued: 4/20/2021
Inventor(s): D’Agostino; Csilla Ari and D’Agostino; Dominic Paul

Title: Grp94 selective inhibitors and uses thereof
Patent number:  10,975,030
Date issued: 4/13/2021
Inventor(s): Mishra; Sanket Jaiprakash, Blagg; Brian S. J. and Dickey; Chad Anthony

Title: Preclinical model of neonatal necrotizing enterocolitis
Patent number:  10,973,932
Date issued: 4/13/2021
Inventor(s): Maheshwari; Akhil and Krishnan; Mohan Kumar

Title: Adjustable prosthetic ankles
Patent number:  10,959,861
Date issued: 3/30/2021
Inventor(s): Highsmith; Michael Jason and Lura; Derek James

Title: Respiratory syncytial virus having altered NS1 protein function and related materials and methods
Patent number:  10,947,512
Date issued: 3/16/2021
Inventor(s): Peeples; Mark Edward, Teng; Michael Nan-hao, Ramilo; Octavio, Mejias; Maria Asuncion and Flano; Emilio

Title: Delaying latency to seizure by combinations of ketone supplements
Patent number:  10,945,975
Date issued: 3/16/2021
Inventor(s): Ari D’Agostino; Csilla, D’Agostino; Dominic Paul and Dean; Jay B.

Title: Incision-less laparoscopic instrument
Patent number:  10,945,750
Date issued: 3/16/2021
Inventor(s): Hart; Stuart, Lai-Yuen; Susana, Moree; Erin, Doulgeris; James, Nelson; Benjamin Taylor, Roach; Grahm and Kruse; Brandon

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Title: Compositions and methods to reduce beta-agonist-mediated tachyphylaxis
Patent number: 10,927,375
Date issued: 2/23/2021
Inventor(s): Liggett; Stephen B.

Title: Smooth muscle specific inhibition for anti-restenotic therapy
Patent number: 10,925,976
Date issued: 2/23/2021
Inventor(s): Totary-Jain; Hana, Marks; Andrew Robert and Marx; Steven O.

Title: Beta-lactamase inhibitors, formulations, and uses thereof
Patent number: 10,864,222
Date issued: 12/15/2020
Inventor(s): Chen; Yu, Pemberton; Orville Antonio, Renslo; Adam and Jaishankar; Priyadarshini

Title: Metabolic therapy for wound healing
Patent number: 10,864,184
Date issued: 12/15/2020
Inventor(s): D’Agostino; Dominic Paul and Kesl; Shannon

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Title: Exosomes from human adipose-derived stem cells for the treatment of brain injury
Patent number: 10,857,187
Date issued:12/8/2020
Inventor(s): Patel; Niketa A. and Bickford; Paula Cole

Title: Sortilin-binding small molecules for increasing glucose uptake
Patent number:  10,849,896
Date issued:  12/1/2020
Inventor(s): Patel; Niketa A., Sparks; Robert Pleasants and Guida; Wayne Charles

Title:  Use of ketone esters for prevention of CNS oxygen toxicity
Patent number:  10,842,767
Date issued: 11/24/2020
Inventor(s): D’Agostino; Dominic Paul, Dean; Jay B., Pilla; Raffaele and Arnold; Patrick

Title:  Compositions and methods for white to beige adipogenesis
Patent number:  10,828,304
Date issued: 11/10/2020
Inventor(s): Cooper; Denise Ratzlaff, Kirchoffer; Ryan Adam, Sparks; Robert Pleasants, and Guida; Wayne Charles

Title: Inhibitors of the FKBP51 protein from a high-throughput drug screen and methods of use
Patent number:  10,821,107
Date issued: 11/3/2020
Inventor(s): Sabbagh; Jonathan Jacob and Dickey; Chad

Title: Recombinant adeno-associated virus-mediated expression of fractalkine for treatment of neuroinflammatory and neurodegenerative diseases
Patent number:  10,815,285
Date issued: 10/27/2020
Inventor(s): Gemma; Carmelina, Bickford; Paula C., Nash; Kevin R., Morganti; Josh and Bachstetter; Adam

Title: Transgenic mouse model for conditional FKBP51 expression and related methods
Patent number:  10,814,015
Date issued: 10/27/2020
Inventor(s): Dickey; Chad, Zhang; Bo and Blair; Laura Jenelle

Title: Methods and compositions for treating drug resistance in cancer
Patent number:  10,813,935
Date issued: 10/27/2020
Inventor(s): Mohapatra; Subhra, Mohapatra; Shyam S., Howell; Mark and Nair; Rajesh

Title: Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
Patent number:  10,813,913
Date issued: 10/27/2020
Inventor(s): Sanchez-Ramos; Juan, Sava; Vasyl, Song; Shijie and Sebti; Said

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Title: Small molecule inhibitors of STAT3 with anti-tumor activity
Patent number:  10,806,712
Date issued: 10/20/20
Inventor(s): Turkson; James, Sebti; Said M., Guida; Wayne, Yip; Man Lun, Lawrence; Nicholas, Lawrence; Harshani Rithma and Greedy; Benjamin 

Title: Bone fusion system
Patent number:  10,799,367
Date issued: 10/13/20
Inventor(s): Vrionis; Frank D., Aghayev; Kamran, Gonzalez Blohm; Sabrina A and Doulgeris; James J. 

Title: Toll-like receptor 2 ligands and methods of making and using thereof
Patent number:  10,793,595
Date issued: 10/6/20
Inventor(s): Morse; David L., Vagner; Josef, McLaughlin; Mark, Gillies; Robert, Huynh; Amanda and Doligalski; Michael 

Title: Method for the treatment of malignancies
Patent number:  10,792,375
Date issued: 10/6/20
Inventor(s): Heller; Richard and Ugen; Kenneth E.  

Title: Methods of sustaining dietary ketosis and its effects on lipid profile
Patent number:  10,792,268
Date issued: 10/6/20
Inventor(s): D’Agostino; Dominic Paul and Kesl; Shannon 

Title: Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
Patent number:  10,780,104
Date issued: 9/22/20
Inventor(s): Cheng; Jin Q. and Sebti; Said M. 

Title: Combinational fendiline formulations and uses thereof
Patent number:  10,772,847
Date issued: 9/15/20
Inventor(s): Padmanabhan; Jaya 

Title: Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers
Patent number:  10,765,706
Date issued: 9/8/20
Inventor(s): Borlongan; Cesario Venturina and Sanberg; Paul R. 

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Title: Reelin rescues cognitive function
Patent number:  10,729,744
Date issued: 8/4/2020
Inventor(s): Weeber; Edwin, Zhao; Lisa and Peters; Melinda    

Title: Methods and compositions for diagnosis and management of diabetes and metabolic syndrome
Patent number:  10,724,097
Date issued: 7/28/2020
Inventor(s): Patel; Niketa A.  

Title: Self-replicating cell selective gene delivery compositions, methods, and uses thereof
Patent number:  10,709,759
Date issued: 7/14/2020
Inventor(s): Totary-Jain; Hana   

Title: Reversible anchoring devices
Patent number:  10,702,372
Date issued: 7/7/2020
Inventor(s): Nofsinger; Charles, Decker; Summer Joy, Ford; Jonathan Michael, Lee; William E., Regel; Charli H. and Dweik; Mahmoud Y. 

Title: Compositions, methods of use, and methods of treatment
Patent number:  10,688,080
Date issued:  6/23/2020
Inventor(s): Chen; Yu, Torelli; Nicholas Joseph, Pemberton; Orville Antonio, Zhang; Xiujun, Renslo; Adam, Defrees; Kyle and Jaishankar; Priyadarshini 

Title: Treating and/or preventing insulin-resistance related weight gain
Patent number:  10,688,063
Date issued: 6/23/2020
Inventor(s): Farese; Robert Vito and Sajan; Mini Paliyath 

Title: Bone fusion system
Patent number:  10,687,876
Date issued: 6/23/2020
Inventor(s): Vrionis; Frank D., Aghayev; Kamran, Gonzalez Blohm; Sabrina A and Doulgeris; James J.  

Title: Compositions and methods for white to beige adipogenesis
Patent number:  10,675,283
Date issued: 6/9/2020
Inventor(s): Cooper; Denise Ratzlaff, Kirchoffer; Ryan Adam, Sparks; Robert Pleasants and Guida; Wayne Charles  

Title: PTEN binding compounds, formulations, and uses thereof
Patent number:  10,669,241
Date issued: 6/2/2020
Inventor(s): Dave; Vrushank G. and Cai; Jianfeng   

Title: Non-toxigenic Clostridium difficile spores for use in oral vaccination
Patent number:  10,668,140
Date issued: 6/2/2020
Inventor(s): Sun; Xingmin and Sonenshein; Abraham  

Title: Method of treating Acanthamoeba infection using allopurinol
Patent number:  10,668,027
Date issued: 6/2/2020
Inventor(s):  Seyfang; Andreas, Locksmith; Timothy J., Bellur; Adarsh, Wells; Deandre and Doenges; Matthew   

Title: ALDA-1 treatment and prevention of pulmonary disease
Patent number:  10,660,873
Date issued: 5/26/2020
Inventor(s): Kolliputi; Narasaiah, Lockey; Richard F. and Galam; Lakshmi 

Title: Inflammatory disease diagnosis and methods of treatment using down-regulators of lipopolysaccharide-responsive beige-like anchor
Patent number:  10,654,918
Date issued: 5/19/2020
Inventor(s): Wang; Jia-Wang and Lockey; Richard F.   

Title: Use of CCL2 to inhibit abnormal uterine bleeding
Patent number:  10,653,750
Date issued: 5/19/2020
Inventor(s): Lockwood; Charles Joseph, Kayisli; Umit Ali, Basar; Murat, Guzeloglu-Kayisli; Ozlem, Semerci; Nihan and Schatz; Frederick 

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Title: Reelin rescues cognitive function
Patent number:  10,729,744
Date issued: 8/4/2020
Inventor(s): Weeber; Edwin, Zhao; Lisa and Peters; Melind  

Title: Methods and compositions for diagnosis and management of diabetes and metabolic syndrome
Patent number:  10,724,097
Date issued: 7/28/2020
Inventor(s): Patel; Niketa A. 

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Title: Compositions and methods for producing elevated and sustained ketosis
Patent number:  10,646,462
Date issued: 05/12/2020
Inventor(s): D’Agostino; Dominic Paul, Arnold; Patrick, Kesl; Shannon

Title: Compositions, methods of use, and methods of treatment
Patent number:  10,604,493
Date issued: 03/31/2020
Inventor(s): Chen; Yu, Nichols; Derek, Renslo; Adam R., Jaishankar; Priyadarshini, Lauterwasser; Erica M. W.

Title: Minimally invasive laparoscopic tissue removal device
Patent number:  10,595,890
Date issued: 03/24/2020
Inventor(s): Hart; Stuart Richard, Esinhart; Erik James, Lytle; Adam Thomas, Kamsler; Daniel Ryan, Drake, III; Charles William, Junaideen; Yasin Ahamed, Simoes; Mario Alves

Title: Noninvasive system and method for mapping epileptic networks and surgical planning
Patent number:  10,588,561
Date issued: 03/17/2020
Inventor(s): Vale; Fernando, Neal; Elliot George

Title: Immunogenic proteins against clostridium difficile
Patent number:  10,555,992
Date issued: 02/11/2020
Inventor(s): Sun; Xingmin

Title: Power morcellation in a protected environment
Patent number:  10,555,747
Date issued: 02/11/2020
Inventor(s): Hoyte; Lennox, Imudia; Anthony

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Title: Beta-lactamase inhibitors, formulations, and uses thereof
Patent number:  10,543,221
Date issued: 01/28/2020
Inventor(s): Chen; Yu, Pemberton; Orville Antonio, Renslo; Adam, Jaishankar; Priyadarshini

Title: System and method of measuring cell viability and growth
Patent number:  10,520,472
Date issued: 12/31/2019
Inventor(s): Mohapatra; Shyam S., Mohapatra; Subhra, Guldiken; Rasim Oytun, Nair; Rajesh R., Wang; Tao

Title: Laparoscopic tool with obturator
Patent number:  10,517,642
Date issued: 12/31/2019
Inventor(s): Hart; Stuart Richard, Simoes; Mario Alves, Zakaria; Mark Antoine

Title: Methods and compositions related to KRAS inhibitors
Patent number:  10,507,228
Date issued: 12/17/2019
Inventor(s): Sebti; Said M., Cai; Jianfeng

Title: Targeted graphene quantum dot-based theranostics
Patent number:  10,493,170
Date issued: 12/03/2019
Inventor(s): Qin; Yiru, Zhou; Shu-Feng

Title: Materials and methods for detecting cancer based on urinary levels of RHAMM
Patent number:  10,473,660
Date issued: 11/12/2019
Inventor(s): Kruk; Patricia Ann, Buttermore; Stephanie Tania

Title: Arginine deiminase gene therapy for disordered proteins
Patent number:  10,435,682
Date issued: 10/08/2019
Inventor(s): Lee; Daniel C., Nash; Kevin Ron

Title: Methods of measuring C19MC miRNA in a post-natal tissue and uses thereof
Patent number:  10,435,757
Date issued: 10/08/2019
Inventor(s): Totary-Jain; Hana, Mong; Ezinne Francess

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Title: Shunt catheter system
Patent number:  10,391,287
Date issued: 8/27/2019
Inventor(s): Beckman, Joshua Marshall

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Title: Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
Patent number:  10,376,495
Date issued: 8/13/2019
Inventor(s): Sanchez-Ramos, Juan; Sava, Vasyl; Song, Shijie; and Sebti, Said

Title: Percutaneous endoscopic gastronomy tube for optimized gastric sumping
Patent number:  10,376,619
Date issued: 8/13/2019
Inventor(s): Daggett, Justin Robert

Title: Adjustable prosthetic ankles
Patent number:  10,369,020
Date issued: 8/6/2019
Inventor(s): Highsmith, Michael Jason; and Lura, Derek James

Title: Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592
Patent number:  10,357,517
Date issued: 7/23/2019
Inventor(s): Borlongan, Cesario Venturina; Gemma, Carmelina; and Vale, Fernando L.

Title: Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases
Patent number:  10,358,405
Date issued: 7/23/2019
Inventor(s): Dickey, Chad; Jinwal, Umesh; Calcul, Laurent; Baker, Bill J.; and Lebar, Matthew

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Title:
Ischemic tissue cell therapy
Patent number:  10,335,434
Date issued: July 2, 2019
Inventor(s): Sanberg; Paul R., and Willing; Alison E.

Title: Compositions and methods for treating stroke
Patent number:  10,328,083
Date issued: June 25, 2019
Inventor(s): Decker; David Andrew, and Pennypacker; Keith

Title: Expandable intervertebral cage
Patent number:  10,322,009
Date issued: June 18, 2019
Inventor(s): Aghayev; Kamran, Doulgeris; James J., Gonzalez Blohm; Sabrina A, and Vrionis; Frank D.

Title: Use of cotinine in treating or preventing neurogenesis deficits and enhancing neurogenesis
Patent number:  10,307,411
Date issued: June 4, 2019
Inventor(s): Moran; Valentina Echeverria, and Appunn; Doreen

Title: Therapeutic agent applicators and methods of using the same
Patent number:  10,300,245
Date issued: May 28, 2019
Inventor(s): Finkelstein; Steven E., Biagioli; Matthew C., and Fishman; Mayer N.

Title: Incision-less laparoscopic instrument
Patent number:  10,292,725
Date issued: May 21, 2019
Inventor(s): Hart; Stuart, Lai-Yuen; Susana, Moree; Erin, Doulgeris; James, Nelson; Benjamin Taylor, Roach; Grahm, and Kruse; Brandon

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Title: Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases
Patent number:  10,287,227
Date issued: 5/14/19
Inventor(s): Dickey, Chad; Jinwal, Umesh; Calcul, Laurent; Baker, Bill J.; and Lebar, Matthew

Title: Non-invasive method for direct delivery of therapeutics to the spinal cord in the treatment of spinal cord pathology
Patent number:  10,285,935
Date issued: 5/14/19
Inventor(s): Garbuzova-Davis, Svitlana; Borlongan, Cesario Venturina; van Loveren, Harry Ronald; and Nelson, Peter Richard

Title: Nanoparticle targeted drug delivery to the lungs using extra-testicular sertoli cells
Patent number:  10,272,053
Date issued: 4/30/19

Inventor(s): Kumar, Arun; Mohapatra, Shyam S.; and Cameron, Don F.
Title:  Transfection vector for pathogenic amoebae and uses thereof
Patent number:  10,273,487
Date issued: 4/30/19
Inventor(s): Seyfang, Andreas; Massengill, Christopher L.; and Sievers, Sara R.

Title: Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with A-beta peptide aggregation
Patent number:  10,238,641
Date issued: 3/26/19
Inventor(s): Echeverria Moran, Valentina

Title: Small molecule inhibitors of STAT3 with anti-tumor activity
Patent number:  10,226,439
Date issued: 3/12/19
Inventor(s): Turkson, James; Sebti, Said M.; Guida, Wayne; Yip, Man Lun; Lawrence, Nicholas; Lawrence, Harshani Rithma; and Greedy, Benjamin

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Title: Stabilized peptoid-peptide hybrids and uses thereof 
Patent number:  10,197,575
Date issued: 02/05/2019
Inventor(s): McLaughlin; Mark and Sarnaik; Amod A.

Title: Method of characterizing and manipulating adipose stem cell depots to a metabolically healthy state
Patent number:  10,196,612
Date issued: 02/05/2019
Inventor(s): Patel; Niketa A. and El Bassit; Ghattas

Title: Self-replicating cell selective gene delivery compositions, methods, and uses thereof 
Patent number:  10,188,750
Date issued: 01/29/2019
Inventor(s): Totary-Jain; Hana

Title: Exo-S-mecamylamine formulation and use in treatment 
Patent number:  10,188,613
Date issued: 01/29/2019
Inventor(s): Shytle; Douglas, Sanberg; Paul R., Newman; Mary and Silver; Archie A.

Title: Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer 
Patent number:  10,184,942
Date issued: 01/22/2019
Inventor(s): Mohapatra; Subhra and Mohapatra; Shyam

Title: Methods and systems for predicting cancer outcome 
Patent number:  10,181,009
Date issued: 1/15/19
Inventor(s): Yeatman; Timothy J., Eschrich; Steven and Bloom; Gregory C.

Title: Afobazole nanoparticles formulation for enhanced therapeutics
Patent number:  10,172,867
Date issued: 1/8/19
Inventor(s): Cuevas; Javier, Katnik; Christopher and Sutariya; Vijaykumar B.

Title: Prevention and treatment of brain diseases and disorders related to abnormal protein aggregation through electromagnetic field treatment 
Patent number:  10,149,982
Date issued: 12/11/2018
Inventor(s): Arendash; Gary W., Cao; Chuanhai, and Tan; Jun

Title: Method of manufacturing a synthetic skin and tissue model
Patent number:  10,150,265
Date issued: 12/11/2018
Inventor(s): Hart; Stuart Richard and Simoes; Mario Alves

Title: Method for the treatment of malignancies
Patent number:  10,143,759
Date issued: 12/04/2018
Inventor(s): Heller; Richard and Ugen; Kenneth E.

Title: Lithium cocrystal compositions 
Patent number:  10,130,708
Date issued: 11/20/19
Inventor(s): Zaworotko; Michael John, Shytle; Roland D., Ong; Tien Teng, Cantwell; Ryan N., Nguyen; Tranhha, Smith; Adam John, and Kavuru; Padmini

Title: Combination therapy of stem cell mobilizing agents and stem cell transplantation
Patent number:  10,130,683
Date issued: 11/20/19
Inventor(s): Borlongan; Cesario Venturina and Sanberg; Paul R.

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