The Diabetes Control and Complications Trial
The Diabetes Control and Complications Trial (DCCT), sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at NIH, proved conclusively that tighter control of blood glucose in people with type 1 diabetes could significantly decrease the incidence of retinopathy (damage to the eyes), nephropathy (damage to the kidneys), and neuropathy (damage to the nerves). Before this trial, there had been no comprehensive data to prove the value of lowering blood glucose levels closer to the normal range. The DCCT proved for type 1 diabetes that it really is important to intensively control blood glucose.
For more information, visit www.nejm.org/doi/full/10.1056/NEJM199309303291401
The Diabetes Prevention Program
The Diabetes Prevention Program, sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at NIH, proved conclusively that prevention or significant delay of onset of type 2 diabetes was possible. This large study showed that a lifestyle intervention worked better than an oral medication in preventing type 2 diabetes. Of interest, older adults in this study (those 60+) reduced their risk of developing type 2 diabetes by significantly higher percentages than their younger counterparts. Additionally, after 10 years of follow-up, reduction of risk of development of type 2 diabetes was still strong.
For more information, visit www.nejm.org/doi/full/10.1056/NEJMoa012512
The Continuous Glucose Monitoring Study Group
The Juvenile Diabetes Research Foundation’s Continuous Glucose Monitoring (CGM) Study Group looked into the value of continuous glucose monitoring in the management of type 1 diabetes in 2008. In this study, continuous glucose monitoring was found to be associated with improved glycemic control in adults with type 1 diabetes.
For more information, visit www.nejm.org/doi/full/10.1056/NEJMoa0805017