Intravenous transplants of human adipose-derived stem cell protect the brain from TBI-induced neurodegeneration and motor and cognitive impairments: Cell graft bio-distribution and soluble factors in young and aged rats” will appear in the Journal of Neuroscience.
Archive for the CEABR Category
A multi-disciplinary team of researchers at the University of South Florida are improving the safety and efficacy of one of the oldest psychiatric drugs in existence. Lithium therapy is still in use today for the treatment of bipolar disorder and other off label uses. Although it is a highly effective medication that is unmatched by any alternatives, patient compliance and adverse events remain problematic.
University of South Florida researchers have suggested a new view of how stem cells may help repair the brain following trauma. In a series of preclinical experiments, they report that transplanted cells appear to build a “biobridge” that links an uninjured brain site where new neural stem cells are born with the damaged region of the brain.
While the effects of acute stroke have been widely studied, brain damage during the subacute phase of stroke has been a neglected area of research. Now, a new study by the University of South Florida reports that within a week of a stroke caused by a blood clot in one side of the brain, the opposite side of the brain shows signs of microvascular injury. Stroke is a leading cause of death and disability in the United States, and increases the risk for dementia. “Approximately 80 percent of strokes are […]
Researchers from the University of South Florida and colleagues at the James A. Haley Veterans’ Hospital studying the long-term consequences of traumatic brain injury (TBI) using rat models, have found that, over time, TBI results in progressive brain deterioration characterized by elevated inflammation and suppressed cell regeneration. However, therapeutic intervention, even in the chronic stage of TBI, may still help prevent cell death. Their study is published online in the current issue of the journal PLOS ONE. “In the U.S., an estimated 1.7 million people suffer from traumatic brain injury,” […]