Dr. Jeffrey Krischer of the USF Health Informatics Institute oversees the new NIH-funded study
Tampa, FL (Sept. 30, 2020) – The USF Health Morsani College of Medicine’s Health Informatics Institute is coordinating a nationwide study funded by the National Institutes of Health (NIH) that seeks to discover the cause of several unusual forms of diabetes. For years, doctors and researchers have been stymied by cases of diabetes that differ from known types. Through research efforts at the University of South Florida (USF) and 19 other U.S. research institutions, the study aims to discover new forms of diabetes, understand what makes them different, and identify their causes.
The Rare and Atypical Diabetes Network, or RADIANT, plans to screen about 2,000 people with unknown or atypical forms of diabetes that do not fit the common features of type 1 and type 2 diabetes.
Dr. Jeffrey Kirscher, who leads the USF Health Informatics Institute, is study chair and director of the coordinating center for the new NIH-funded RADIANT study. He also oversees TEDDY and TrialNet, both NIH-sponsored international clinical networks investigating the causes and outcomes of type 1 diabetes. | Photo by Allison Long, USF Health Communications
A person with atypical diabetes may be diagnosed and treated for type 1 or type 2 diabetes, but not have a history or signs consistent with their diagnosis. For example, they may be diagnosed and treated for type 2 diabetes but may not have any of the typical risk factors for this diagnosis, such as being overweight, having a family history of diabetes, or being diagnosed as an adult. Alternately, a person with atypical diabetes may respond differently than expected to the standard diabetes treatments.
“With help from participants and their families, we aim to develop a comprehensive description of the genetic and clinical characteristics of these rare forms of diabetes,” said RADIANT Study Chair and Coordinating Center Director Dr. Jeffrey Krischer, director of the USF Health Informatics Institute and a professor in the Morsani College of Medicine’s Department of Internal Medicine. “This information could help to establish new diagnostic criteria for diabetes, find new markers for screening, or identify drug targets for new therapies that could ultimately bring precision medicine to diabetes.”
RADIANT researchers will build a comprehensive resource of genetic, clinical, and descriptive data on previously unidentified forms of diabetes for the scientific and health care communities.
The study’s researchers will collect detailed health information using questionnaires, physical exams, genetic sequencing, blood samples, and other tests. People found to have unknown forms of diabetes may receive additional testing. Some participant family members may also be invited to take part in the study.
“It’s extremely frustrating for people with atypical diabetes when their diabetes seems so different and difficult to manage,” said the study’s project scientist, Dr. Christine Lee of NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). “Through RADIANT, we want to help patients and the broader health care community by finding and studying new types of diabetes to shed light on how and why diabetes can vary so greatly.”
USF is the study’s coordinating center, and the lead centers include Baylor College of Medicine in Houston and the University of Chicago. The Broad Institute in Cambridge, Massachusetts, and Baylor serve as the genomic sequencing centers for the project. University of Florida, Gainesville, provides the study’s laboratory services. Other participating centers are:
- Columbia University, New York City
- Duke University, Durham, North Carolina
- Geisinger Health System, Danville, Pennsylvania
- Indiana University, Indianapolis
- Massachusetts General Hospital, Boston
- NorthShore University Health System, Chicago
- Seattle Children’s Hospital
- SUNY Downstate Health Sciences University, Brooklyn
- University of Colorado, Denver
- University of Maryland, Baltimore
- University of Michigan, Ann Arbor
- University of North Carolina, Chapel Hill
- University of Washington, Seattle
- Vanderbilt University, Nashville, Tennessee
- Washington University in St. Louis
“The RADIANT study will further clarify diabetes as a disease that has many different forms, and for which diagnosis and management for some of those forms remain a challenge,” said NIDDK Director Dr. Griffin P. Rodgers. “The discoveries of the study should provide critical understanding of the spectrum of diabetes and improve lives of people with rare forms of diabetes and everyone who cares for them.”
The study opened recruitment on Sept. 30, 2020 for people with atypical diabetes or a form of diabetes that seems different from known types of diabetes. Visit for more information on the study and how to join.
Support for the study is provided through NIDDK grants U54DK118638 and U54DK118612.
